发明名称 |
Arginine deiminase derived from mycoplasma arthritidis and polymer conjugates containing the same |
摘要 |
A purified arginine deiminase (ADI) obtained from Mycoplasma arthritidis having the amino acid sequence of SEQ ID NO:2 as well as an isolated nucleic acid molecule containing a nucleotide sequence encoding the amino acid sequence set forth in SEQ ID NO:1 are disclosed. Other aspects of the invention include an expression vector, a cloned gene for expressing the Mycoplasma arthritidis derived ADI, (recombinant) host cells useful in expressing the ADI of the present invention and substantially non-antigenic polymer conjugates containing the ADI of the present invention as well as methods of treating arginine deiminase susceptible conditions in mammals. The arginine deiminase-polymer conjugates have high levels of retained enzyme activity and relatively long circulating lives.
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申请公布号 |
US5804183(A) |
申请公布日期 |
1998.09.08 |
申请号 |
US19970792283 |
申请日期 |
1997.01.31 |
申请人 |
ENZON, INC. |
发明人 |
FILPULA, DAVID RAY;WANG, MAOLIANG |
分类号 |
C12N15/09;A61K38/00;A61K38/46;A61K38/50;A61K47/48;A61P35/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/78;C12N11/08;C12N11/10;C12R1/35;(IPC1-7):A61K38/46;A61K38/43 |
主分类号 |
C12N15/09 |
代理机构 |
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