| 摘要 |
FIELD: organic technology; pharmacology. SUBSTANCE: derivative of ergoline having formula I <EMI ID=0.462 HE=66 WI=45 TI=CHI> wherein R<SB>1</SB>-C<SB>2</SB>H<SB>5</SB>,R<SB>2</SB>-(CH<SB>2</SB>)<SB>3</SB>N(CH<SB>3</SB>)<SB>2</SB>,, R<SB>3</SB> is allyl, R<SB>4</SB>=R<SB>5</SB>=H is prepared by interaction of ergoline amide having formula II <EMI ID=0.463 HE=54 WI=42 TI=CHI> with 1-4 equivalents of isocyanate having formula III <EMI ID=0.464 HE=9 WI=15 TI=CHI>. In formulae II and III R<SB>1</SB>,R<SB>2</SB>,R<SB>3</SB>,R<SB>4</SB> and R<SB>5</SB> are as mentioned above; interaction is carried out in 1,1-dichloroethane or in toluene at 35-60 C in the presence of CuCl and in the presence of phosphorous compound chosen of PPh<SB>3</SB>,P(pClPh)<SB>3</SB>,P(pMePh)<SB>3</SB> and MePh<SB>2</SB>P. Compounds having formula I are suitable as antiprolactinic and antiparcinsonic agents. EFFECT: improved efficiency of the method. |
