| 摘要 |
PCT No. PCT/GB95/00833 Sec. 371 Date Jan. 17, 1997 Sec. 102(e) Date Jan. 17, 1997 PCT Filed Apr. 12, 1995 PCT Pub. No. WO95/28392 PCT Pub. Date Oct. 26, 1995The invention provides amphiphilic compounds of the formula (I) Ch-(-L-Ar-(-AH)n)m (where Ch is a hydrophilic chelant moiety or a salt or a chelate thereof); each L is an optionally oxo substituted C2-25-alkylene linker wherein at least one CH2 moiety is replaced by a group X1 (e.g. L may include a chain sequence, an X1(CH2CH2X1)u (where u is a positive integer) such as X1(CH2CH2X1)u, CH2X1CH2CH2X1CH2CH2X1, CH2X1CH2CH2X1CH2CH2X1CH2CH2X1, etc.), and wherein L is optionally interrupted by a metabolizable group M but with the provisos that the terminus of L adjacent Ch is CH2 and that the terminus of L adjacent Ar is X1 or a CH2 group adjacent or separated by one CH2 from a group X1 (thus, for example the L-Ar linkage may be L1-X1-Ar, L1-CH2-Ar, L1-X1CH2-Ar or L1-X1CH2CH2-Ar, where L1 is the residue of L; each Ar is an aryl ring optionally substituted by or having fused thereto a further aryl ring; each AH is a protic acid group, preferably an oxyacid, e.g. a carbon, sulphur or phosphorus oxyacid or a salt thereof; each X1 is O, S, NR1 or PR1, preferably no more than 3 X1 groups being present in L; each R1 is hydrogen, alkyl or aryl; and m and n are positive integers, m being for example 1 to 4, especially 1 or 2 and n being for example, 1, 2 or 3) which are especially suited for use in diagnostic imaging of the hepatobiliary system.
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