发明名称 |
Therapeutic treatment and prevention of infections with a bioactive material encapsulated within biodegradable-biocompatible polymeric matrix |
摘要 |
Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group, and end-capped forms ranging in ratios from 100/0 to 1/99. |
申请公布号 |
AU6317598(A) |
申请公布日期 |
1998.08.18 |
申请号 |
AU19980063175 |
申请日期 |
1998.01.27 |
申请人 |
UNITED STATES GOVERNMENT REPRESENTED BY THE SECRETARY OF THE AR |
发明人 |
JEAN A SETTERSTROM;JOHN E. VAN HAMONT;ROBERT H REID;ELLIOT JACOB;RAMASUBBU JEYANTHI;EDGAR C BOEDEKER;CHARLES E. MCQUEEN;THOMAS R. TICE;F. DONALD ROBERTS;PHIL FRIDEN |
分类号 |
A61K9/16;A61K9/50;A61K9/52;A61K38/17;A61K38/19;A61K39/00;A61K39/02;A61K39/108;A61K39/29;F23G5/50;G05B23/02 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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