| 摘要 |
The present invention discloses the use of permanently charged steroid agonists or antagonists as potent anti-angiogenic compositions comprising as an active ingredient a compound of general formulae (I), (II) or (III), wherein DRUG is any steroid agonist or antagonist, a mixed agonist-antagonist, or a partial agonist and the substituents are as defined in the specification. The effects of estradiol, tamoxifen, TMI or a placebo on the growth or MCF-7 tumors implanted in the vnetral fat pad of nude mice (see the figure). The left panel gives data for tamoxifen, TMI and the placebo, while the right panel adds the group treated with estradiol.
|
