发明名称 |
Treatment of diabetes with synthetic beta cells |
摘要 |
Hepatocytes transfected with a replication deficient adenovirus vector containing a gene cassette expressing the proinsulin gene in response to physiological levels of glucose provide novel beta islet replacement cells. The cassette comprises the structural gene for human proinsulin genetically altered to make it cleavable to active insulin, a promoter operably linked to the proinsulin gene, and a glucose regulatory response module located 5' to the promoter. Synthesis of proinsulin mRNA is ablated at less than 5mM glucose, and peaks at about 15mM. |
申请公布号 |
AU5926998(A) |
申请公布日期 |
1998.08.07 |
申请号 |
AU19980059269 |
申请日期 |
1998.01.21 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION. |
发明人 |
DEBRA A. HULLETT;TAUSIF ALAM;HANS W. SOLLINGER |
分类号 |
A61K38/00;A61K48/00;C07K14/62;C07K14/765;C12N15/85 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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