MORPHOGENIC PROTEINS

摘要

DAN (differential-screening-selected gene Aberrative in Neuroblastoma) and b57 proteins and related nucleic acids are provided. Included are natural DAN or b57 homologs from several species and proteins comprising a DAN or b57 domain having specific activity, particularly the ability to antagonize a bone morphogenic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.