发明名称 |
METHOD FOR ANALYZING DNA FROM A RARE CELL IN A CELL POPULATION |
摘要 |
Methods are provided for analyzing DNA of a rare cell in a cell population. In one embodiment, the method involves covering a cell monolayer with a photosensitive material. By illuminating the area over a cell of interest, the material is solidified, permitting manipulation of the underlying cell and/or protection of the cell from DNA-inactivating agents that destroy DNA in other cells in the monolayer. In another embodiment, the monolayer is overlaid with a solid material that becomes soluble when illuminated. By illuminating the area over a cell of interest, that cell can be specifically exposed and DNA from the cell amplified. The methods are particularly useful for analyzing fetal cells found in maternal blood.
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申请公布号 |
WO9830384(A1) |
申请公布日期 |
1998.07.16 |
申请号 |
WO1998US00389 |
申请日期 |
1998.01.09 |
申请人 |
APPLIED IMAGING CORPORATION;SAUNDERS, ALEXANDER, MICHAEL |
发明人 |
SAUNDERS, ALEXANDER, MICHAEL |
分类号 |
C12Q1/68;G01N1/30;(IPC1-7):B31F5/00;B44C1/165;B32B31/00;C09J4/00;A01N3/00;A61F13/02;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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