发明名称 |
MULTIPLE BRANCH PEPTIDE CONSTRUCTIONS |
摘要 |
Multiple branch peptide constructions formed from peptides derived from the envelope transmembrane glycoprotein gp41 of HIV, and including the consensus sequence RQGY preceded by 0 to 4 amino acid residues and succeeded by 2 to 4 amino acid residues, most preferably RQGYSPL, show increased receptor affinity and prevent cell-to-cell fusion. They have a direct virostatic effect. Because they present the same peptide sequence several times, these MBPCs are able to neutralize in vitro the different steps of virus envelope/cell membrane fusion, and infected cell membrane/uninfected cell membrane fusion of several strains of HIV-1 and HIV-2. These results open a potential use in treatment of HIV infection.
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申请公布号 |
WO9829443(A1) |
申请公布日期 |
1998.07.09 |
申请号 |
WO1997EP07334 |
申请日期 |
1997.12.30 |
申请人 |
ARMEL S.A.;MABROUK, KAMEL;SABATIER, JEAN-MARC;ROCHAT, HERVE;VAN RIETSCHOTEN, JURPHAAS |
发明人 |
MABROUK, KAMEL;SABATIER, JEAN-MARC;ROCHAT, HERVE;VAN RIETSCHOTEN, JURPHAAS |
分类号 |
A61K38/00;C07K14/16;(IPC1-7):C07K14/16;A61K38/16 |
主分类号 |
A61K38/00 |
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