Animals with targeted disruptions of the genes encoding G-CSF, M-CSF or GM-CSF

摘要

PCT No. PCT/AU94/00103 Sec. 371 Date Oct. 24, 1994 Sec. 102(e) Date Oct. 24, 1994 PCT Filed Mar. 4, 1994 PCT Pub. No. WO95/23862 PCT Pub. Date Sep. 8, 1995The invention provides transgenic non-human animals in which genes encoding colony-stimulating factors have been specifically disrupted, so that the animals do not express the respective factors. In specific embodiments the invention provides mice in which expression of GM-CSF, G-CSF and/or CSF-1 is disrupted. These animals do not produce any bioactive CSF of the respective type. They are useful as models for a variety of conditions, and particularly for testing of therapeutic methods.