| 发明名称 |
DNA encoding the beta subunit of a mammalian maxi-K potassium channel |
| 摘要 |
PCT No. PCT/US95/05768 Sec. 371 Date Nov. 12, 1996 Sec. 102(e) Date Nov. 12, 1996 PCT Filed May 9, 1995 PCT Pub. No. WO95/31543 PCT Pub. Date Nov. 23, 1995This invention relates to a heteromultimer and its use in screening pharmaceutically active compounds for modulators of maxi-K channel activity. Such modulators are useful in treating asthma, pregnant human myometrium, hypertension and angina, cerebral ischemia and in conditions where stimulation of neurotransmitter release is desired such as Alzheimer's disease and stimulation of damaged nerves.
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| 申请公布号 |
US5776734(A) |
申请公布日期 |
1998.07.07 |
| 申请号 |
US19960732506 |
申请日期 |
1996.11.12 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
KACZOROWSKI, GREGORY J.;GARCIA, MARIA L.;LEONARD, REID J.;MCMANUS, OWEN B.;SWANSON, RICHARD J.;FOLANDER, KIMBERLY L. |
| 分类号 |
C12N15/09;A61K38/00;A61P9/00;A61P9/08;A61P9/10;A61P13/02;A61P15/00;A61P21/02;A61P25/04;A61P29/00;C07H21/04;C07K14/47;C07K14/705;C07K16/18;C12N1/19;C12N5/10;C12N15/12;C12P21/02;C12R1/865;C12R1/91;(IPC1-7):C12N15/12 |
主分类号 |
C12N15/09 |
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