Substituted 3-(Pyridinylamino)-indoles and benzo[b]thiophenes, a process for their preparation and their use as medicaments

摘要

The present invention relates to compounds of the formula I where R1 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, aminoloweralkyl, loweralkylaminoloweralkyl, formyl, loweralkylcarbonyl, aminoloweralkylcarbonyl or loweralkoxycarbonyl; the group -X-Y= is R2 and R3 being independently hydrogen or loweralkyl; W is hydrogen, halogen, hydroxy, loweralkoxy, arylloweralkoxy or where R4 is hydrogen, loweralkyl or arylloweralkyl; R5 is loweralkyl or arylloweralkyl; or alternatively the group as a whole is , R6 being hydrogen, loweralkyl, aryl or arylloweralkyl; and Z is hydrogen, halogen, loweralkyl, nitro or amino; which are useful for alleviating various memory dysfunctions such as Alzheimer's disease, as modulators of neurotransmitter functions such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorders.