| 摘要 |
An object of the present invention is to offer a novel inhibitor for the production of 3-deoxyglucosone which is an intermediate in Maillard reaction and induces a crosslinking glycation of proteins participating in various diseases. The inhibitor for the production of 3-deoxyglucosone (3-DG) in accordance with the present invention contains at least one of parabanic acid derivatives represented by the following formula (I) or pharmaceutically acceptable salts thereof as an effective ingredient. (see fig. I) ¢In the formula, R is hydrogen or lower alkyl; X is hydrogen, alkyl, cycloalkyl, lower alkylcycloalkyl, phenyl or phenylalkyl which is optionally substituted with lower alkyl, lower alkoxy, nitro and/or halogen; and n is an integer of from 1 to 4.! The compound of the present invention has an action of inhibiting the production of 3-DG which is a highly active intermediate and participates in a protein crosslinked formation in Maillard reaction and, therefore, said compound is useful in the treatment and the prevention of various diseases induced by deposition into tissues or sclerosis or denaturation of crosslinked protein, similar diseases induced by aging and diabetic complications.
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