| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject compound useful for treatment and prevention of heterolipidemia or atherosclerosis. SOLUTION: This compound is expressed by formula I [A is an 6-10C aryl; D is formula II or III (R<5> and R<6> are each a 3-8C cycloalkyl; X is an alkylene of 8C or less and the like; R<7> is H and a halogen; R<8> is H, a halogen, an azide, etc.); E is a 3-8C cycloalkyl and the like; R<1> and R<2> are combined to form an 6C alkylene chain], its salt and the N-oxide, e.g. 3-ethyl 5-methyl 6- cyclopentyl-4-(4-fluorophenyl)-2-oxo-1,2,3,4-tetrahydropyridine-3,5-di carboxylate. The compound is obtained by initially introducing the substituent D into the compound of formula IV by Grignard reaction or Wittig reaction using organic metal reagents in an inactive solvent followed by suitably converting or introducing substituents illustrated as A, E and/or R<1> and R<2> by ordinary processes. |
