发明名称 |
Gene transcription and ionizing radiation: methods and compositions |
摘要 |
The present invention provides a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an encoding region that encodes at least one polypeptide. An encoding region can comprise a single encoding sequence for a polypeptide or two or more encoding sequences encoding DNA binding, activation or repression domains of a transcription factor. Processes for regulating polypeptide expression and inhibiting tumor growth using such DNA molecules are also provided.
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申请公布号 |
US5770581(A) |
申请公布日期 |
1998.06.23 |
申请号 |
US19950474445 |
申请日期 |
1995.06.07 |
申请人 |
ARCH DEVELOPMENT CORP.;DANA-FARBER CANCER INSTITUTE |
发明人 |
WEICHSELBAUM, RALPH R.;HALLAHAN, DENNIS E.;SUKHATME, VIKAS P.;KUFE, DONALD W. |
分类号 |
C12N15/09;A61K31/70;A61K38/00;A61K41/00;A61K48/00;A61K51/00;A61P9/08;A61P9/10;A61P35/00;C07H21/04;C07K14/52;C07K14/525;C07K14/82;C12N5/10;C12N15/63;C12N15/67;C12N15/85;G03G15/20;(IPC1-7):A61K48/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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