| 摘要 |
<p>Stereoselective synthesis of one chiral form of an amine of formula (IA) or (IB) in amt. greater than the other, where R1, R2 = different alkyl or aryl opt. substd. with an enzymatically non-inhibiting gp.; comprises contacting a ketone of formula R1-CO-R2 (II) with an omega-amino acid transaminase in the presence of an amine donor at least until a substantial amt. of one of the chiral amines is formed. Process for enantiomeric enrichment of a mixt. of enantiomeric chiral amines (IA) and (IB) comprises contacting the mixt., in aq. medium in presence of an amino acceptor, with an omega-amino acid transaminase which is enzymatically active w.r.t. the NH2 gp. of one of the chiral amines, at least until a substantial amt. of one of the amines is converted to ketone (II). (II) may be isolated from the medium and converted to chiral amine as above; and/or the chiral amine which is not converted to (II) may be recovered.</p> |
