发明名称 |
SELF-ENHANCING, PHARMACOLOGICALLY CONTROLLABLE EXPRESSION SYSTEMS |
摘要 |
The invention relates to a nucleic acid construct which constitutes a self-enhancing expression system and which comprises the following components: at least one first structural gene that encodes an active compound; at least one second structural gene that encodes a transcription factor protein; and at least one activation sequence comprised of at least one sequence that binds the transcription factor protein and at least one promoter sequence; wherein each activation sequence activates the expression of a structural gene and the expression of the transcription factor protein; and to the use of the nucleic acid construct for preparing a drug for treating diseases.
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申请公布号 |
CA2224334(A1) |
申请公布日期 |
1998.06.11 |
申请号 |
CA19972224334 |
申请日期 |
1997.12.10 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
SEDLACEK, HANS-HARALD;MUELLER, ROLF |
分类号 |
C12N15/09;A61K31/70;A61K38/00;A61K38/47;A61K48/00;A61P3/00;A61P7/00;A61P7/02;A61P25/00;A61P29/00;A61P31/04;A61P31/12;A61P33/00;A61P35/00;A61P35/02;A61P37/00;C07K16/18;C07K19/00;C12N5/10;C12N15/00;C12N15/56;C12N15/62;C12N15/63;C12N15/67;C12N15/85;C12P21/02;(IPC1-7):C12N15/67 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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