摘要 |
This invention provides a compound of the following formula: <CHEM> and the pharmaceutically acceptable salts thereof wherein Ar is phenyl, C3-8 cycloalkyl, C4-8 cycloalkenyl or heteroaryl; X<2> and X<3> are independently C1-4 alkyl, halo, halo-substituted C1-4 alkyl, hydroxy, C1-4 alkoxy, mercapto, C1-4 alkylthio, C1-4 alkylsulfinyl, C1-4 alkylsulfonyl or the like; X<1> is H, halo, C1-4 alkyl, hydroxy, cyano, nitro, C1-4 alkylthio, C1-4 alkylsulfinyl, C1-4 alkylsulfonyl or the like; Y is -CR<1>=CR<2>- or -C IDENTICAL C-, wherein R<1> and R<2> are independently H, methyl, ethyl or halo; and 1 is 0, 1, 2, 3 or 4; m and n are independently 0, 1, 2 or 3,with the proviso that when Ar is phenyl; and 1, m and n are 0, Y is not -CH=CH-; and when Ar is phenyl; I and m are 0; n is 1; and Y is -CH=CH-, X<3> is not C1-4 alkoxy attached to the 2- position of Ar, nor amino, C1-4 alkylamino or di(C1-4)alkyÜamino attached at 4-position of Ar; and a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens. |