发明名称 Composition and methods for the treatment of tumors
摘要 The invention concerns a method for inducing a selective collapse of the vasculature of a solid tumor by administering to a patient a therapeutically effective dose of a combination of a compound preventing the formation of a functional thrombin-thrombomodulin complex and a cytokine selected from the group of TNF- beta (LT), TNF- alpha , IL-1, and IFN- gamma . The invention further concerns the composition used in this method.
申请公布号 US5762921(A) 申请公布日期 1998.06.09
申请号 US19960594360 申请日期 1996.01.30
申请人 GENENTECH, INC. 发明人 VEHAR, GORDON A.
分类号 C12N15/02;A61K38/00;A61K38/06;A61K38/21;A61K38/22;A61K38/43;A61K38/46;A61K38/48;A61K38/55;A61K39/395;A61K45/00;A61P35/02;C07K16/18;C07K16/40;C12N5/10;C12P21/08;(IPC1-7):A61K45/05;A61K38/19;C07K1/00 主分类号 C12N15/02
代理机构 代理人
主权项
地址