MODULATION OF IgG BINDING TO FcRn

摘要

Disclosed are mutant IgG molecules having altered amino acid sequences in the FcRn-binding region. These changes confere increased or decreased affinity for FcRn and thus, respectively, a decreased or increased rate of clearance from the systemic circulation. Such molecules can be attached to detectable labels or cytotoxic moieties for imaging tissues or for delivering cytotoxins. Also disclosed is a method for identifying IgG molecules with altered half-lives in circulation by contacting the molecules with FcRn.