发明名称 |
Huntingtin-related therapeutics and bioassay |
摘要 |
A method of identifying a compound useful in the treatment of a disease characterized by the presence of mutant huntingtin by: (a) providing a cell which expresses mutant huntingtin; (b) contacting the cell with a test compound; and (c) determining whether the level of clathrin-mediated endocytosis is increased in the presence of the test compound, compared to the level in the absence of the test compound. An increase in clathrin-mediated endocytosis is an indication that the test compound is useful in treating the disease. |
申请公布号 |
AU7180498(A) |
申请公布日期 |
1998.06.03 |
申请号 |
AU19980071804 |
申请日期 |
1997.11.14 |
申请人 |
UNIVERSITY OF MASSACHUSETTS |
发明人 |
MARIAN DILFIGLIA;NEIL ARONIN;JAMES VELIER |
分类号 |
G01N33/50;G01N33/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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