发明名称 |
PHARMACEUTICAL PREPARATIONS FOR THE CONTROLLED RELEASE OF beta -LACTAM ANTIBIOTICS |
摘要 |
The present invention relates to a pharmaceutical controlled-release oral drug delivery system comprising as active ingredient at least one beta -lactam antibiotic agent, having a specific absorption site in the small intestine in combination with a polymeric matrix, optionally further containing additional pharmaceutically acceptable constituents, wherein at least 50 % of the beta -lactam antibiotic agent are released from the matrix within from about 3 to about 4 hours from oral administration and the remainder of the pharmaceutical agent is released at a controlled rate. The drug delivery system according to the invention optionally further comprises a beta -lactamase inhibitor, preferably in combination with amoxicillin and/or amoxicillin trihydrate as the active ingredient. The polymeric matrix of the pharmaceutical controlled-release oral drug delivery system of the invention may be of hydrophilic and/or hydrophobic nature and the delivery system may further comprise pharmaceutically acceptable additive. The pharmaceutical controlled-release oral drug delivery system of the invention is preferably in dosage unit form.
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申请公布号 |
WO9822091(A1) |
申请公布日期 |
1998.05.28 |
申请号 |
WO1997IL00368 |
申请日期 |
1997.11.13 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW;KATZHENDLER, IFAT;HOFFMAN, AMNON;FRIEDMAN, MICHAEL |
发明人 |
KATZHENDLER, IFAT;HOFFMAN, AMNON;FRIEDMAN, MICHAEL |
分类号 |
A61K9/20;A61K9/26;A61K31/43;A61K31/545;(IPC1-7):A61K9/10;A61K9/22;A61K9/24;A61K9/66;A61K47/32;A61K47/36;A61K47/38;A61K47/42;A61K47/44 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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