| 摘要 |
1387630 Medicines comprising 3-amino-1- phenoxy-2-propanols IMPERIAL CHEMICAL INDUSTRIES Ltd 24 April 1972 [7 May 1971] 13720/71 Heading A5B [Also in Division C2] Novel compounds I in which R<SP>1</SP> is C 1-6 alkyl, hydroxy C 1-6 alkyl or C 3-6 cycloalkyl, R<SP>2</SP> is cyano or C 1-6 acyl, R<SP>3</SP> is hydrogen, halogen, C 1-6 alkyl, C 1-6 alkoxy, C 2-6 alkenyl or C 2-6 alkenyloxy and A is C 1-6 alkylene and the acid addition salts thereof have #-adrenergic blocking activity and form with a diluent or carrier a pharmaceutical composition which may be administered orally or parenterally. The composition may contain further drugs selected from sedatives (phenobarbitone, meprobamate, chlorpromazine and benzodiazepines) vasodilators (glyceryl trinitrate, pentaerythritol and isorbide dinitrate), diuretics (chlorthiazide), hypotensive agents (reserpine, bethamidine and guanethidine), agents for Parkinson's disease (benzhexol), cardiotonic agents (digitalis preparations) and sympathomimetic bronchodilators (isoprenaline, orciprenaline, adrenaline and ephedrine). |
