发明名称 Conformationally restricted polyamines and their use as antineoplastic agents
摘要 Compounds of the Formula (I): E-NH-D-NH-B-A-B-NH-D-NH-E, wherein A is C2-C6 alkene, C3-C6 cycloalkyl, cycloalkenyl, or cycloaryl; B is independently a single bond, C1-C6 alkyl alkenyl; D is independently C1-C6 alkyl or alkenyl, or C3-C6 cycloalkyl, cycloalkenyl, or cycloaryl; and E is independently H, C1-C6 alkyl or alkenyl; and pharmaceutically suitable salts thereof; a synthetic method therefor, pharmaceutical dosage forms containing one of more of these compounds, and use of these compounds in the treatment of neoplastic cell growth, are disclosed.
申请公布号 AU4900797(A) 申请公布日期 1998.05.15
申请号 AU19970049007 申请日期 1997.10.15
申请人 WISCONSIN ALUMNI RESEARCH FOUNDATION. 发明人 BENJAMIN J. FRYDMAN;LAURENCE J. MARTON;VENDOHAR K. REDDY;ALDONIA L. VALASINAS;DONALD T WITIAK
分类号 A61P35/00;A61K31/132;C07C209/62;C07C211/14;C07C211/18;C07C211/22;C07C211/36 主分类号 A61P35/00
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