PROCESS FOR ISOLATING GLYCOMACROPEPTIDE FROM DAIRY PRODUCTS WITH A PHENYLALANINE IMPURITY OF 0.5 %W/W

摘要

A process for purifying GMP from milk derived starting materials on a production level scale is disclosed wherein the purified GMP has an amino acid composition containing not greater than about 0.5 %(w/w) phenylalanine (PHE). Such a purified GMP product may be used as a dietary supplement for PKU patients. The process comprises contacting a GMP containing feedstock with an anion exchanger under conditions which adsorb the GMP, eluting the GMP, removing the impurities therefrom in a number of alternative ways, and recovering the purified GMP.