发明名称 |
TREATMENT OF FUNGAL INFECTIONS USING A COMBINATION OF AN ANTI-FUNGAL COMPOUND AND AN N-ALKYL HETEROCYCLIC COMPOUND |
摘要 |
A method for increasing the effectiveness of an anti-fungal compound is described. In the method, an anti-fungal compound and an N-alkyl heterocyclic compound or a salt thereof are administered to a mammal in a combined amount effective to treat a fungal infection. The N-alkyl heterocyclic compound or salt thereof is present in an amount effective to potentiate or increase the anti-fungal activity of the anti-fungal compound. The N-alkyl heterocyclic compound has formula (I). The variable "n" ranges from 5 to 17, and the heterocyclic ring defined by formula (a) is a substituted or unsubstituted ring having four to eight members. A pharmaceutical composition is described where the anti-fungal compound and the N-alkyl heterocyclic compound or salt thereof are present in a combined amount effective to treat a fungal infection. A method for controlling the growth of fungal organisms on various substrates to be inserted into the body using a combined amount of an anti-fungal compound and an N-alkyl heterocyclic compound or a salt thereof is also described. 00000 |
申请公布号 |
WO9806265(A3) |
申请公布日期 |
1998.03.19 |
申请号 |
WO1997US13902 |
申请日期 |
1997.08.08 |
申请人 |
BUCKMAN LABORATORIES INTERNATIONAL, INC. |
发明人 |
WHITTEMORE, MARILYN, S. |
分类号 |
C07D295/02;A01N43/653;A01N61/00;A61K31/40;A61K31/415;A61K31/495;A61K31/535;A61K31/5375;A61K45/00;A61K45/06;A61P31/10;C07D207/263 |
主分类号 |
C07D295/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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