The invention relates to a means to a herpesvirus saimiri that has been genetically modified by mutating and/or deleting specific essential and non-essential genes. The essential genes are required in replication of viral genes and are needed for viral proliferation. The non-essential genes can represent sites for the insertion of heterologous genetic material, namely therapeutic genes.
申请公布号
WO9810083(A1)
申请公布日期
1998.03.12
申请号
WO1997GB02371
申请日期
1997.09.04
申请人
THE UNIVERSITY OF LEEDS;MEREDITH, DAVID, MARK;MARKHAM, ALEXANDER, FRED