NEW BRUCELLA ANTIGENS, RECOMBINANT POLYPEPTIDES, NUCLEIC ACIDS CODING FOR THE SAME AND USE THEREOF IN DIAGNOSTIC AND PROPHYLACTIC METHODS AND KITS

摘要

The present invention relates to isolated and pure Brucella antigens, to nucleic acids encoding said antigens, as well as to diagnostic methods and kits using said antigens and nucleic acids for detecting Brucella infection in human and cattle. The invention also relates to recombinant polypeptides, a process for preparing the same and their use in methods and kits for the diagnosis of Brucella infection. The invention also relates to the use of said isolated antigens, or said recombinant polypeptides, or said nucleic acids as an active principle of a vaccine composition against Brucella infection. The invention relates also to a vaccine composition comprising a recombinant Brucella strain, specifically deleted for the gene(s) encoding said antigen(s).