NOVEL PYRIMIDINE DERIVATIVES EFFICACIOUS AS PSYCHOTROPIC DRUG AND PROCESS FOR THE PRODUCTION THEREOF

摘要

A compound represented by the formula, or a pharmacologically acceptable salt thereof: <CHEM> wherein A<1> is a halogen atom, a lower alkyl group, a cycloalkyl group, a substituted lower alkyl group or a substituted cycloalkyl group; B<1> and B<2>, which may be the same or different, are hydrogen atoms, amino groups or substituted amino groups; X is a sulfur atom or an oxygen atom; and Y<1>, Y<2>, Y<3>, Y<4> and Y<5>, which may be the same or different, are hydrogen atoms, halogen atoms, lower alkyl groups, cycloalkyl groups, lower alkenyl groups, lower alkynyl groups, aryl groups, heterocyclic groups, substituted lower alkyl groups, substituted cycloalkyl groups, substituted lower alkenyl groups, substituted lower alkynyl groups, substituted aryl groups, or substituted heterocyclic groups, interacts strongly with receptors of central nervous system, such as dopamine, serotonin and the like, is excellent in bioabsorbability, stability and the like, and hence is very useful as a psychotropic drug having reduced side effects.