发明名称 |
ASSAY FOR QUANTIFYING ARTHRITIC CONDITIONS |
摘要 |
The present invention is drawn to a novel and newly discovered low molecular weight protein fragments that are degradation products of COMP and have a molecular weight of about 14-33 kilodaltons and polyclonal and monoclonal antibodies to the new COMP fragment and other known COMP fragments of molecular weight 67-80 kDa and 150-250 kDa, and thrombospondin fragments (collectivvly referred to as "ADP") as well as an assay to measure the level of ADP comprising: (1) incubating a body fluid sample, which has been obtained from an arthritis patient, under reducing or non-reducing conditions; (2) incubating the body fluid sample with an anti-ADP antibody; and (3) measuring the level of bound anti-ADP antibody in the body fluid sample. Also disclosed is an assay to measure the ratio of ADP to KS as a diagnostic measure of arthritic disease. |
申请公布号 |
WO9807035(A1) |
申请公布日期 |
1998.02.19 |
申请号 |
WO1997EP04316 |
申请日期 |
1997.08.08 |
申请人 |
NOVARTIS AG;GANU, VISHWAS |
发明人 |
GANU, VISHWAS |
分类号 |
G01N33/53;C07K14/78;C07K16/18;G01N33/543;G01N33/68;(IPC1-7):G01N33/68;C07K14/47;G01N33/564;G01N33/577 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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