A reliable and quantifiable measure of multidrug resistance based on a functional assay of fluorescent dye exclusion from cells. As herein disclosed, the selection of a fluorescent substrate having slow transmembrane movement results in an improved assay overcoming many of the shortcomings of existing MDR assays.
申请公布号
WO9807034(A1)
申请公布日期
1998.02.19
申请号
WO1997US14083
申请日期
1997.08.12
申请人
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.;FRIEDMAN, MARK, M.;EYTAN, GERA;ASSARAF, YEHUDA