发明名称 |
Covalently cross-linked oligonucleotides |
摘要 |
Covalent cross-linkages for two oligonucleotide strands or for first and second regions of a single oligonucleotide strand connect sugar moieties of nucleotides on the respective strands or the regions of the single strand. The cross-linkages are connected to at least one strand or region via a space-spanning group. The cross-linkage also can be connected to the other strand or other region via a space-spanning group or via an abasic site located on the other strand or other region.
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申请公布号 |
US5719271(A) |
申请公布日期 |
1998.02.17 |
申请号 |
US19940295743 |
申请日期 |
1994.08.30 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
COOK, PHILLIP DAN;MANOHARAN, MUTHIAH;BRUICE, THOMAS |
分类号 |
C12N15/09;C07H21/00;C07H21/04;(IPC1-7):C07H21/00;C07H21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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