发明名称 |
SUBSTITUTED VINYLUREA DERIVATIVES AND MEDICINE CONTAINING THE SAME |
摘要 |
Disclosed herein are substituted vinylurea derivatives represented by the following general formula (1): <IMG> (1) wherein R1 and R3 are independently a phenyl group which may be substituted, R2 is a phenyl group which may be substituted, or a cycloalkyl group, and wave lines mean that the bonding state may be either E or Z, with the proviso that the cases where R1, R2 and R3 are unsubstituted phenyl groups, and where R1 and R2 are unsubstituted phenyl groups and R3 is a 4-ethoxyphenyl group are excluded, or salt thereof, and medicines comprising such a derivative as an active ingredient as well as a method of preventing and treating arteriosclerosis with such a medicine. The derivatives or salts thereof selectively and strongly inhibit ACAT in macrophages and are hence useful as prophylactic and therapeutic agents for arteriosclerosis.
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申请公布号 |
CA2211945(A1) |
申请公布日期 |
1998.02.09 |
申请号 |
CA19972211945 |
申请日期 |
1997.07.29 |
申请人 |
SS PHARMACEUTICAL CO., LTD. |
发明人 |
OHTSUKA, MARI;SHIBATA, AKIHIRO;TACHIBANA, KOICHI;KANAMARU, YOSHIHIKO;ISHII, FUMIO;NAITO, HIROYUKI;HIROTA, HIROYUKI;KOMOTO, TERUO;SATO, SUSUMU |
分类号 |
C07C275/28;C07C275/30;C07C275/34;C07C275/40;C07C275/42;C07C317/42;C07C323/44;C07D211/58;C07D317/58;C07D317/66;(IPC1-7):C07C275/28;A61K31/16;C07D295/185;A61K31/185;C07D295/215;A61K31/235;A61K31/275;A61K31/335;A61K31/445;C07C311/47;A61K31/495;C07C309/51;C07D317/68 |
主分类号 |
C07C275/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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