EGF-LIKE FACTOR FROM CHROMAFFIN GRANULES AND GLIA CELL-DERIVED NEUROTROPHIC FACTOR WITH SURVIVAL-PROMOTING ACTIVITY ON DAERGIC NEURONS

摘要

The present invention relates to chromaffin granule-derived EGF-like proteins that are involved in promoting survival of DAergic neurons, to nucleotide sequences encoding said proteins or a functionally active derivative or part thereof, and to processes for their preparation. The present invention relates further on to glia cell-derived neurotrophic factors that are capable of promoting survival of DAergic neurons, to nucleotide sequences encoding said factors or a functionally active derivative or part thereof, and to a process for their preparation.