GENE THERAPY USING GENE FUSION FOR GENETIC OR ACQUIRED DISORDERS
摘要
The present invention is related generally to the construction of fusion genes. More particularly, the present invention is related to the construction of a fusion gene comprising a coding sequence for a selectable marker linked by fusion to another coding sequence, the product of which is desired to be expressed in recipient cells. Gene therapy utilizing an MDR1 linked fusion coding sequence has been disclosed. Adenosine deaminase activity has been introduced into cells using MDR1 linked fusion gene.
申请公布号
CA1339654(C)
申请公布日期
1998.02.03
申请号
CA19890601635
申请日期
1989.06.02
申请人
UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE (THE);UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE (THE)
发明人
GERMANN, URSULA A.;PASTAN, IRA H.;GOTTESMAN, MICHAEL M.
