发明名称 |
HIGH DOSE LIPOSOMAL AEROSOL FORMULATIONS |
摘要 |
The present invention provides a high dose pharmaceutical liposome aerosol composition comprising about 12-30 mg/ml of a pharmaceutical compound, and about 130-375 mg of a phospholipid/ml starting reservoir concentration. Specifically, the present invention is drawn to anti-inflammatory glucocorticoids, immunosuppressive compounds, anti-fungal compounds, antibiotic compounds, anti-viral compounds, and anti-cancer compounds delivered via a high dose liposome aerosol composition in a phospholipid. More specifically, the invention provides a high dose cyclosporin A liposome aerosol composition comprising up to about 30 mg/ml cyclosporin A in up to about 225 mg of a phospholipid/ml starting reservoir concentration. Also provided is a high dose budesonide-liposome aerosol composition comprising up to about 15 mg/ml budesonide in up to about 225 mg of a phospholipid/ml starting reservoir concentration.
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申请公布号 |
CA2259185(A1) |
申请公布日期 |
1998.01.08 |
申请号 |
CA19972259185 |
申请日期 |
1997.07.02 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
BLACK, MELANIE B.;KNIGHT, VERNON;WALDREP, J. CLIFFORD |
分类号 |
A61K9/72;A61K9/00;A61K9/12;A61K9/127;A61K31/58;A61K38/00;A61K38/13;A61P11/00;(IPC1-7):A61K47/24;A61K31/34 |
主分类号 |
A61K9/72 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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