摘要 |
Genetically engineered cells are provided which can serve as universal donor cells in such applications as reconstruction of vascular linings or the administration of therapeutic agents. The cells include a coding region which provides protection against complement-based lysis, i.e., hyperacute rejection. In addition, the cell's natural genome is changed so that functional proteins encoded by either the class II or both the class I and the class II major histocompatibility complex genes do not appear on the cell's surface. In this way, attack by T-cells is avoided. Optionally, the cells can include a self-destruction mechanism so that they can be removed from the host when no longer needed.
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申请人 |
OKLAHOMA MEDICAL RESEARCH FOUNDATION;YALE UNIVERSITY |
发明人 |
SIMS, PETER J.;BOTHWELL, ALFRED L.M.;ELLIOT, EILEEN A.;FLAVELL, RICHARD A.;MADRI, JOSEPH;ROLLINS, SCOTT;BELL, LEONARD;SQUINTO, STEPHEN |