PEPTIDES WITH GROWTH PROMOTION PROPERTIES.

摘要

Peptides are described which have well-defined secondary structure, preferably a helical conformation, which mimic the corresponding region of porcine somatotropin (pST) and which enhance the activity of pST and promote growth of warm-blooded animals. These peptides compete with pST for binding to the PS-7.6 monoclonal antibody. These peptides contain therein the sequence of amino acids Xaa-Xaa-Leu-Xaa-Xaa-Ile-Xaa-Xaa-Xaa-Leu-Xaa-Xaa-Val-Xaa-Xaa (SEQ ID No. 1), wherein the sequence differs from the native sequence of pST, as well as sequences in which the location of essential amino acids is shifted by three amino acids, representing almost one turn along the helix, which contain therein the sequence of amino acids Xaa-Xaa-Xaa-Xaa-Xaa-Leu-Xaa-Xaa-Xaa-Ile-Xaa-Xaa-Leu-Xaa-Xaa- Xaa-Val (SEQ ID No. 18) and wherein the sequence differs from the native sequence of pST.