发明名称 |
Interruption of binding of MDM2 and p53 protein and therapeutic application thereof |
摘要 |
A method of identifying a compound which interferes with the binding of MDM2 to human p53 has been determined. This method comprises forming a mixture between MDM2 and a fragment of human p53 consisting of 6 to 28 amino acids comprising TFSDLW (SEQ ID NO:2), adding a test compound to the mixture and determining the quantity of protein bound to the other before and after adding the compound. A compound which decreases the amount of binding of the two proteins to each other is a compound which interferes with the binding of MDM2 to human p53.
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申请公布号 |
US5702908(A) |
申请公布日期 |
1997.12.30 |
申请号 |
US19940277660 |
申请日期 |
1994.07.20 |
申请人 |
UNIVERSITY OF DUNDEE |
发明人 |
PICKSLEY, STEVEN MICHAEL;LANE, DAVID PHILIP |
分类号 |
A61K38/00;A61K48/00;C07K14/47;C07K14/82;(IPC1-7):G01N33/53 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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