发明名称 |
RACEMIZATION PROCESS FOR OPTICALLY ACTIVE CARBOXYLIC ACIDS OR SALTS OR ESTERS THEREOF |
摘要 |
Optically active carboxylic acids, salts or esters, such as the profen-type compounds, are racemized in the presence by nitrogenous bases such as methylbenzyl-amine by heating an aqueous solution of such optically active compounds at a temperature of from 80 ~C to 200 ~C in the presence of a catalytically effective amount of an alkali metal hydroxide. The process not only enables conversion of inactive or undesirable enantiomers of compounds such as Naproxen or Ibuprofen into a usable, desirable enatiomers in an efficient and economical manner, but avoids conversion of the nitrogenous base into amide. Thus the deleterious consequences of amide formation are avoided.
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申请公布号 |
CA2258085(A1) |
申请公布日期 |
1997.12.18 |
申请号 |
CA19972258085 |
申请日期 |
1997.06.10 |
申请人 |
ALBEMARLE CORPORATION |
发明人 |
MANIMARAN, THANIKAVELU;ZUMSTEIN, RONALD C.;PHAN, HAO V.;YOUNG, ROBERT E. |
分类号 |
C07B55/00;C07C51/487;C07C55/00;C07C59/68;C07C67/333;(IPC1-7):C07C59/68;C07D207/20;C07D333/24;C07C319/26;C07C57/30;C07C51/42;C07C67/48;C07C57/58;C07C69/612;C07C69/736;C07C69/738;C07C59/84 |
主分类号 |
C07B55/00 |
代理机构 |
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