CEPHALOSPORIN COMPOUNDS, THEIR PHARMACEUTICALLY ACCEPTABLE NONTOXIC SALTS, PHYSIOLOGICALLY HYDROLYZABLE ESTERS, ISOMERS HAVING E-CONFIGURATION OF DOUBLE BOND IN PROPENYL GROUP, SYN-ISOMERS AND OPTICAL ISOMERS AND A METHOD OF THEIR SYNTHESIS

摘要

The present invention relates to a cephalosporin compound represented by the following general formula (I) : its pharmaceutically acceptable non-toxic salt, physiologically hydrolyzable ester, hydrate or solvate, or isomers thereof, in which R<1> represents hydrogen or an amino-protecting group, R<2> and R<3> can be identical or different and independently of one another represent hydrogen or a hydroxy-protecting group, or R<2> and R<3> together can form a cyclic diol-protecting group, R<4> represents hydrogen or a carboxyl-protecting group, R<5>, R<6> and R<7> independently of one another represent hydrogen, amino or substituted amino, hydroxy, alkoxy, C1-4 alkyl, carboxyl or alkoxycarbonyl, or R<5> and R<6> together with the carbon atoms to which they are attached can form a C3-7 cycle, and Q represents CH or N, and to a process for preparation thereof and a pharmaceutical composition containing the compound (I) as an active ingredient.