ARYL GLYCINAMIDE DERIVATIVES, METHODS OF PRODUCING THESE SUBSTANCES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS.

摘要

The invention concerns novel aryl glycinamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof, the symbols having the following meanings: R1 and R2 together with the nitrogen atom to which they are bound form a ring of formula (II) shown in which p is 2 or 3 and X stands for oxygen, N(CH2)nR6 or CR7R8; and R3, R4, R5, R6, R7, R8, Ar and n have the meanings indicated in the description. The invention also concerns the production and use of these substances. The novel compounds are valuable neurokinin (tachykinin) antagonists.