发明名称 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
摘要 The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
申请公布号 WO9738665(A3) 申请公布日期 1997.11.27
申请号 WO1997US06487 申请日期 1997.03.27
申请人 MERCK & CO., INC.;ANTHONY, NEVILLE, J.;DINSMORE, CHRISTOPHER;GOMEZ, ROBERT, P.;HUTCHINSON, JOHN, H.;WAI, JOHN, S.;WILLIAMS, THERESA, M.;BELL, IAN, M.;EMBREY, MARK, W.;FISHER, THORSTEN, E. 发明人 ANTHONY, NEVILLE, J.;DINSMORE, CHRISTOPHER;GOMEZ, ROBERT, P.;HUTCHINSON, JOHN, H.;WAI, JOHN, S.;WILLIAMS, THERESA, M.;BELL, IAN, M.;EMBREY, MARK, W.;FISHER, THORSTEN, E.
分类号 A61K31/445;A61K31/454;A61K31/4545;A61K31/4709;A61P9/00;A61P13/12;A61P27/02;A61P31/12;A61P35/00;A61P43/00;C07D211/62;C07D401/06;C07D401/12;C07D401/14;C07D413/14 主分类号 A61K31/445
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