发明名称 |
RET LIGAND (RetL) FOR STIMULATING NEURAL AND RENAL GROWTH |
摘要 |
This invention relates to nucleotide sequences which encode a Ret ligant (RetL9, as well as to methods of stimulating neural and renal growth by treating cells and mammalian subjects with RetL DNA or protein. The invention provides a purified and isolated DNA molecule coding for a RetL, having the nucleotide sequence of any RetL, but specifically including rat retL 1 cDNA (SEQ ID NO.1), partial human RetL1 cDNA (SEQ ID NO:8), full length human retL 1 cDNA (SEQ ID NO:10), human retL2 cDNA (SEQ ID NO:12), murine retL3 cDNA (SEQ ID NO:12) or human retL3 cDNA (SEQ ID NO;16), partial human retL3 cDNA (SEQ ID NO:18) or human retL3 cDNA (SEQ ID NO:20). The invention further provides a RetL protein, with an amino acid sequence comprising that of rat RetL1 (SEQ ID NO:2), partial human RetL1 (SEQ ID NO:9), full length human RetL (SEQ ID NO:11), human RetL2 (SEQ ID NO:13), murine RetL3 (SEQ ID NO:17), partial human RetL3 (SEQ ID NO:19) or human RetL3 (SEQ ID NO:21). |
申请公布号 |
WO9744356(A2) |
申请公布日期 |
1997.11.27 |
申请号 |
WO1997US07726 |
申请日期 |
1997.05.07 |
申请人 |
BIOGEN, INC.;SANICOLA-NADEL, MICHELE;HESSION, CATHERINE;CATE, RICHARD, L. |
发明人 |
SANICOLA-NADEL, MICHELE;HESSION, CATHERINE;CATE, RICHARD, L. |
分类号 |
C07K14/47;C12N15/09;A61K31/70;A61K35/76;A61K38/00;A61K38/17;A61K38/18;A61K39/395;A61K47/48;A61K48/00;A61P13/12;A61P25/00;C07K14/71;C07K14/72;C07K16/18;C07K16/28;C07K19/00;C12N;C12N1/15;C12N1/19;C12N1/21;C12N5/06;C12N5/10;C12N15/12;C12N15/62;C12N15/63;C12P21/02;C12Q1/68;G01N33/15;G01N33/566;G01N33/74 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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