Antisense oligonucleotides complementary to the primary transcript of the human c-fes protooncogene and their use, combined with a differentiation inducer to cause apoptosis of leukemic blast cells

摘要

The following description sets forth antisense (AS) oligonucleotides (ODNs) complementary to the primary transcript of the human c-fes protooncogene and their use to inactivate said transcript. All-trans retinoic acid (ATRA) is reported to be used as a differentiation inducer on cells pretreated with said AS-ODNs to induce apoptosis of leukemic blast cells.