Prenyl transferase (farnesyl pyrophosphate synthase) and/or isopentenyl pyrophosphate isomerase inhibitors find application in various forms of the therapy and prophylaxis. The use of such inhibitors in the treatment of various diseases and disorders of bone metabolism in the screening, isolation, synthesis and the valuation of osteoactive drugs as hypolipidaemic and as anti-cancer agents is also described.
申请公布号
WO9743437(A2)
申请公布日期
1997.11.20
申请号
WO1997GB01302
申请日期
1997.05.12
申请人
THE UNIVERSITY OF SHEFFIELD;BROWN, RICHARD, JOHN;WATTS, DONALD, JEREMY;RUSSEL, ROBERT, GRAHAM, GOODWIN;ROGERS, MICHAEL, JOHN,