Novel muscarinic receptor agonists

摘要

Muscarinic receptor agonists of the formula:- <CHEM> wherein X is NR<4>R<5>, (C1-C10)alkyl or optionally substituted (C3-C10)cycloalkyl, n is an integer from one to three; m is an integer from one to three; p is an integer from one to three; Y is N or CH; Z is NR<7>R<8>, optionally substituted (C3-C10)cycloalkyl, (C1-C10)alkyl, pyridyl or optionally substituted phenyl; R<2> is optionally substituted phenyl; R<3> is optionally substituted phenyl; R<4> and R<5> are independently (C1-C10)alkyl or R<4> and R<5> taken together with the nitrogen atom to which they are attached form a (five to nine)-membered saturated heterocyclic ring. R<6> is hydrogen or (C1-C6)alkyl; and R<7> and R<8> are independently (C1-C10)alkyl or R<7> and R<8> taken together with the nitrogen atom to which they are attached form a (five to seven)-membered saturated heterocyclic ring.