发明名称 Treatment of ischemias by administration of 2,N6-substituted adenosines
摘要 The present invention relates to compounds of formula I <IMAGE> (I) wherein X is amino, C1-6-alkylamino, di-C1-6-alkylamino; R1 is H, straight or branched C1-6-alkyl or trifluoromethyl; R4 is H or straight or branched C1-6-alkyl; or R1 and R4 together form a cyclobutyl, cyclopentyl or cyclohexyl ring; Y is O, S, SO2, N-H or N-alkyl; R5 is selected from optionally substituted heterocycles; R6 is hydrogen, benzoyl or C1-6-alkanoyl and R7 is hydrogen, benzoyl or C1-6-alkanoyl; or a pharmaceutically acceptable salt thereof. The compounds have been found useful for treating central nervous system and cardiovascular ailments.
申请公布号 US5683989(A) 申请公布日期 1997.11.04
申请号 US19950504811 申请日期 1995.07.20
申请人 NOVO NORDISK A/S 发明人 LAU, JESPER;KNUTSEN, LARS JACOB STRAY;SHEARDOWN, MALCOLM;HANSEN, ANKER JON
分类号 C07H19/16;(IPC1-7):A61K31/70;C07H19/167 主分类号 C07H19/16
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