发明名称 |
ANTIARRHYTHMIC (S)-ENANTIOMERS OF METHANESULFONAMIDES. |
摘要 |
<p>(S)-Enantiomeric methanesulfonamides are structurally depicted by formula (I) or its pharmacologically acceptable salts where R3 is a C1-9 alkyl substituted with one fluorine atom. These compounds are useful as Class III antiarrhythmic agents without the undesirable side effect of polymorphic ventricular tachycardia (PVT) and are stable against rapid metabolism. Use of the compounds of formula (I) in the preparation of compositions for treating cardiac arrhythmias are also described.</p> |
申请公布号 |
MX9705192(A) |
申请公布日期 |
1997.10.31 |
申请号 |
MX19970005192 |
申请日期 |
1995.12.21 |
申请人 |
PHARMACIA & UPJHON COMPANY |
发明人 |
JACKSON B. HESTER JR.;J. KENNETH GIBSON |
分类号 |
C07C311/08;(IPC1-7):C07C311/08;A61K31/18 |
主分类号 |
C07C311/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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