发明名称 |
3-[(1,2,3,4-TETRAHYDROISOQUINOLINE-2-YL)METHYL]-8-AZABICYCLO[3.2.1]OCTANE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS |
摘要 |
Compounds of general formula (I) in which each of R1, R2 and R3 represents a hydrogen or halogen atom or a hydroxy, alkyl or alkoxy group, R4 represents a hydrogen or halogen atom or an alkyl, 2-methoxyethoxy, alkoxy, cycloalkylmethoxy or phenylmethoxy group, or R3 and R4 together form a methylenedioxy group, Z represents oxygen or two hydrogen atoms and R represents an ethoxy group when Z represents oxygen, or represents a phenyl group optionally substituted by one or more halogen atoms or alkyl, alkoxy or amino groups. The compounds have a strong affinity for dopamine receptors of D2 and D3 type and for serotonin receptors of 5-HT1A and 5-HT2 type and are mixed ligands. Other compounds have a strong affinity for the dopamine receptors of D3 type and a weak affinity for the dopamine receptors of D2 type and serotonin receptors of 5-HT1A and 5-HT2 and are therefore selective and specific ligands.
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申请公布号 |
CA2251335(A1) |
申请公布日期 |
1997.10.23 |
申请号 |
CA19972251335 |
申请日期 |
1997.04.10 |
申请人 |
SYNTHELABO |
发明人 |
SEVRIN, MIREILLE;MERLY, JEAN-PIERRE;GEORGE, PASCAL;MARABOUT, BENOIT |
分类号 |
C07D491/20;A61K31/47;C07D451/02;(IPC1-7):C07D451/02;C07D519/00 |
主分类号 |
C07D491/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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